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. 2016 Jun 13;10:158. doi: 10.3389/fncel.2016.00158

Figure 4.

Figure 4

Effect of SI and progesterone treatment on input resistance in DG granule cells. (A) Representative traces of holding current changes in response to hyperpolarizing voltage steps (from −65 to −85 mV, Δ 5 mV) in a sample neuron from each experimental group. (B–E) Scatter plot of all experimental groups representing the I/V curves in the presence of 1 μM THIP without and with the application of 20 μM bicuculline. (F) Bar graph of the averaged Rin from the I/V curves graphed in (B–E) [n, 16 (GH), 14 (SI), 11 (GH+Prog), 10 (SI+Prog)]. (G) Bar graph of the averaged effect of bicuculline on Rin in all experimental groups (n, 5 neurons per each group). *p < 0.05; **p < 0.001; ***p < 0.0001 vs. GH (one-way ANOVA, and Bonferroni’s post hoc test).