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. 2016 Jun 13;10:158. doi: 10.3389/fncel.2016.00158

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Copyright © 2016 Talani, Biggio, Licheri, Locci, Biggio and Sanna.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of SI and progesterone treatment on I_h recorded in DG granule cells. (A) Representative traces obtained from a single DG granule cell from GH mice in the absence (left) and presence (right) of the hyperpolarization activated cyclic nucleotide-gated (HCN) selective antagonist ZD7288 (20 μM). (B) Representative traces of I_h recored at −105 mV. Current amplitude is highlighted by the black arrow. (C,D) Bar graph representing the change in I_h amplitude in absolute values (−pA) (C) and as current density (pA/pF) (D) in the different neurons in all experimental groups [n, 16 (GH), 21 (SI), 10 (GH+Prog), 10 (SI+Prog)].