Table 3. IgH and IgL diversity estimates.

The “SPECIES” module for R was used to estimate the diversity of the combinations of germline V, D, and J segments (IgH chain) or V and J segments (light chain) in the population of antibodies specific for HA, based on sampled IgH and IgL sequences. Estimates and 95% confidence intervals (CI) are shown for each method.

VDJ (H)		VJ (L)
Estimate	95% CI	Estimate	95% CI	Reference
113	55–321	35	29–60	Chao (1984)
75	47–148	38	30–60	Chao & Lee (1992) (ACE method)
92	51–223	38	29–63	Chao & Lee (1992) (ACE-1 method)
72	40–171	35	28–60	Chao & Bunge (2002)
111	63–159	39	29–49	Burnham & Overton (1978), Burnham & Overton (1979)
129	47–251	38	28–80	Wang & Lindsay (2005)
97	63–114	37	32–71	Wang (2010)