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. 2016 Jun 13;6:27819. doi: 10.1038/srep27819

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Copyright © 2016, Macmillan Publishers Limited

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Male [C57BL/6 × FVB]F1 TRAMP mice (16 weeks of age) were allowed to spontaneously develop PC and injected with glipizide (5 mg/kg) or DMSO (control) once every three days for 8 weeks. After the mice were sacrificed, the GU tracts were harvested and weighed. (A) The images show the representative gross appearance of the GU tracts from TRAMP mice treated with glipizide and DMSO. (B) There is a significant difference between the relative GU weights of glipizide- or DMSO-treated tumors. (C) Representative H&E images of DP tissues from TRAMP mice treated with DMSO and glipizide. (D) The lesion scoring in every prostate lobe of DMSO- and glipizide- treated TRAMP mice. (E) The lesion distribution in the individual prostate lobes of DMSO- and glipizide-treated TRAMP mice. *p < 0.05; **p < 0.01.