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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: J Neurochem. 2015 Nov 6;136(1):48–62. doi: 10.1111/jnc.13383

Fig. 5. Vinorelbine and epirubicin bind with and stimulate neurite outgrowth via MARCKS.

Fig. 5

(A) Neurite lengths of cerebellar neurons in the presence of 1 nM vinorelbine, 1 nM epirubicin and 30 μg/ml colominic acid, and the MARCKS-ED and control peptides (20 μg/ml). Data represent mean values of neurite lengths per cell + SEM as compared with PLL from three independent experiments. Asterisks denote significant differences from control, * p < 0.001; one-way analysis of variance (ANOVA). Hatches denote differences within a group, # p < 0.001. (B) MARCKS-ED was incubated with PBS (without competitor), colominic acid (CA), vinorelbine or epirubicin followed by addition of PSA mimicking peptide coupled to biotin. Binding of PSA mimicking peptide was detected with Streptavidin-HRP. Means + SD from triplicates and three independent experiments are shown. * p < 0.05.