Table 1.

Summary Table of Scaffold Properties, Reference Sources, and Key Findings

Fiber category	Subcategory	References	Key findings
Material type	Natural	14,16,17,22,45–56,59	Natural or synthetic fibers support RPE growth to a statistically indistinguishable amount.
	Hybrid	15
	Synthetic	18–20,25–27,58,59
Scaffold structure	Nonporous membrane	15,24,25,27,58	Nanofiber scaffolds cause RPE to develop a more physiologically functional phenotype over that of nonporous membranes
	Porous membrane	12,13,28–30
	Nanofiber scaffold	14–20,22,25–27,45–56,58,59
Diameter	<200 nm	15,27	Nanofibers between 150 and 400 nm optimally support RPE growth and function. No direct comparisons between 150 and 400 nm scaffolds have been performed.
	200–400 nm	24,56
	400–1,000 nm	25,56
	>1,000 nm	18,56,57
Surface Modification	Peptide	18	Enhancing cell adhesion through peptides, proteins, or plasma treatment increases RPE viability and functionality.
	Polymer composition	26
	Protein	18,57
	Plasma (O2, N2)	19,57

RPE, retinal pigment epithelium.