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. 2016 Apr 29;59(11):5416–5431. doi: 10.1021/acs.jmedchem.6b00275

Table 4. Solubility in Physiologically Relevant Mediaa.

  solubility (μg/mL)
media 1b 35 11 13 7 9
0.1 N HCl 6.8 180 189 52 429 105
FeSSIF pH 5.0 27.6c 65c 211c 39 211 36
FaSSIF pH 6.5 5.1 15 13 8.3 47 12
a

Solubility after 5–6 h at 37 °C. FaSSIF = fasted state simulated intestinal fluid. FeSSIF = fed state simulated intestinal fluid.

b

Data from ref (12).

c

pH 5.8.