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. 2016 Apr 20;7(6):558–562. doi: 10.1021/acsmedchemlett.5b00234

Table 3. Antiviral Activity of Compounds 43–56.

graphic file with name ml-2015-00234s_0005.jpg

compds R1 R3 R5 R6 EC50 (μM) CC50 (μM)
43 H NH2 CH3 H 0.091 >100
44 H NH2 Et H 0.556 >100
45 H NH2 CH3 CH3 0.028 >100
46 H NH2 Et Et 0.624 >100
47 H NH2 (CH2)2 0.017 >100
48 H NH2 (CH2)3 0.086 >100
49 H NH2 (CH2)4 3.820 >100
50 H NHMe CH3 CH3 0.033 >100
51 H NMe2 CH3 CH3 0.929 55.18
52 H NHAc CH3 CH3 15.580 >100
53 H OH CH3 CH3 0.322 >100
54 5-Cl NH2 CH3 CH3 7.955 20.83
55 6-Cl NH2 CH3 CH3 0.099 20.83
56 7-Cl NH2 CH3 CH3 2.189 20.89