Table 4. DMPK Profiles of RSV Fusion Inhibitorsa,b.
| 45 | 50 | |
|---|---|---|
| HLM (mL min–1 kg–1) | 8.4 | 5.7 |
| RLM (mL min–1 kg–1) | 16.6 | 18.0 |
| CL (mL min–1 kg–1) | 222.0 | 142.6 |
| Vss (L kg–1) | 36.9 | 67.9 |
| T1/2 (h) | 3.0 | 7.3 |
| F (%) | 57.0 | 41.0 |
a
Scaled intrinsic clearance of compounds in human liver microsome (HLM) and rat liver microsome (RLM). Experiments were run in duplicate.
b
The single-dose pharmacokinetics (SDPK) study in male Wistar rats was carried out according to the standard procedures. Major parameters, including plasma clearance (CL), T1/2 (i.v.), Vss (i.v.), and oral bioavailability (F) are reported.