Table 1. Binding Data of the Synthesized Compounds 11–31 for 5-HT₆R.

compd	Q	R	R1	5-HT6Ki [nM]a
Ib	2-napthtyl	H	H	27 ± 6
11	3-quinolinyl	H	H	13 ± 3
12	6-quinolinyl	H	H	20 ± 4
13	7-quinolinyl	H	H	7 ± 2
14	3-isoquinolinyl	H	H	12 ± 1
15	4-isoquinolinyl	H	H	5 ± 1
16	3-quinolinyl	5-Cl	H	11 ± 2
17	5-quinolinyl	5-Cl	H	11 ± 3
18	7-quinolinyl	5-Cl	H	9 ± 2
19	4-isoquinolinyl	5-Cl	H	18 ± 3
IIb	2-napthtyl	5-MeO	H	19 ± 2
20	3-quinolinyl	5-MeO	H	8 ± 1
21	5-quinolinyl	5-MeO	H	4 ± 1
22	6-quinolinyl	5-MeO	H	14 ± 3
23	7-quinolinyl	5-MeO	H	2 ± 0.4
24	3-isoquinolinyl	5-MeO	H	6 ± 1
25	4-isoquinolinyl	5-MeO	H	3 ± 0.2
26	3-quinolinyl	6-Cl	H	37 ± 5
27	6-quinolinyl	6-Cl	H	112 ± 9
28	7-quinolinyl	6-Cl	H	22 ± 2
29	3-isoquinolinyl	6-Cl	H	102 ± 12
30	7-quinolinyl	H	Me	18 ± 3
31	3-isoquinolinyl	H	Me	20 ± 2

^aMean K_i values ± SEM based on three independent binding experiments.

^bData from ref (13).