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. 2016 Apr 7;7(6):618–622. doi: 10.1021/acsmedchemlett.6b00056

Table 3. Binding Data of the Selected Compounds for 5-HT6, 5-HT1A, 5-HT2A, 5-HT7, and D2Rs.

graphic file with name ml-2016-00056b_0009.jpg

      Ki [nM]a
compd Q R 5-HT6 5-HT1A 5-HT2A 5-HT7 D2
12 6-quinolinyl H 20 1872 1412 6660 1410
18 7-quinolinyl 5-Cl 9 2467 2589 7322 1168
21 5-quinolinyl 5-MeO 4 2944 1552 2352 302
23 7-quinolinyl 5-MeO 2 5036 1003 6248 240
25 4-isoquinolinyl 5-MeO 3 5009 3355 7832 3319
a

Mean Ki values (SEM ± 27%) based on two independent binding experiments.