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. 2016 Apr 7;7(6):618–622. doi: 10.1021/acsmedchemlett.6b00056

Table 4. Antagonist Activity of Selected Compounds 23 and 25 for 5-HT6R.

  5-HT6
 %inha
compd Ki [nM] Kb [nM]a α1 α 2C H1 M1 M5 5-HT2C SerT
23 2 ± 0.4 4.4 41 18 9 11 NT 18 4
25 3 ± 0.2 5.6 40 21 15 0 3 15 6
a

Kb values and percentage of inhibition were determined at Eurofins Cerep.