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. 2016 Jun 13;6:27903. doi: 10.1038/srep27903

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Copyright © 2016, Macmillan Publishers Limited

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(a) Top left panel shows effective silencing of TRPV4 expression. Bottom left and right panels show that Trpv4 siRNA inhibited the migration of 4T07 cells. (b) Trpv4 siRNAs inhibited the chemotaxis, invasion, transendothelial migration but not proliferation of 4T07 cells. For all, except proliferation, knock down of Trpv4 produced statistically significant effect on the cellular processes studied, p < 0.05. (c) Shows the inhibitory effects of RR and RES on cell migration and (d) invasion of 4T07 cells but not 67NR cells. Average values (n = 3, ± s.d.) from three biological repeats and p values from unpaired Student’s t-test are shown.