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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2015 Dec 29;292:40–55. doi: 10.1016/j.taap.2015.12.020

Figure 9.

Figure 9

APAP-protein adducts in HepaRG cells pretreated or not with the CYP2E1 inhibitor CMZ and subsequently treated with APAP. HepaRG cells were incubated for 1 week with different conditions of incubation with 100 mM stearic acid (C18:0), 100 mM oleic acid (C18:1), two concentrations of insulin and 150 mM CMZ and subsequently treated or not with 2.5 or 20 mM APAP. APAP-protein adducts were measured 6 hours after APAP treatment. Results are means ± SEM for 3 independent cultures. The letters ns indicate that there was no significant effect of fatty acids or insulin with a two-way ANOVA analysis.