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. Author manuscript; available in PMC: 2016 Jun 13.
Published in final edited form as: Cell Rep. 2016 Jan 28;14(6):1477–1487. doi: 10.1016/j.celrep.2015.12.105

Figure 7. Fluvastatin rescues toxicity caused by other drugs.

Figure 7

(A) 2 μM trametinib was toxic to control flies; toxicity was rescued by 50 μM fluvastatin (Flu; p≤0.05). The proteasome inhibitor bortezomib (bor; p≤0.05) and three mTOR inhibitors—everolimus (eve; p≤0.01), rapamycin (rap; p≤0.05) and temserolimus (tem; p≤0.05)—were also toxic at the specified doses (μM). All were partially rescued by 50 μM fluvastatin.

(B, C) Mutant lines of the Drosophila homologs of HMG-CoA reductase and farnesyl pyrophosphate synthase were insensitive to trametinib and/or everolimus toxicity.

P values are *≤0.05, **≤0.01, ***≤0.01, ****≤0.0001; values represent mean ± SEM.