Table 3.

Previously published results of cerebral metabolic rate of oxygen, glucose and lactate during hypoxia.

Study	Findings	Number of subjects	Methods	Comment
Kety and Schmidt1	−CMRO2	7	Kety-Schmidt	10% FiO2
Cohen et al.5	−CMRO2	9	Kety-Schmidt	6.9–7.5% FiO2
	↑CMRglu
	↑CMRlac
Xu et al.3	↑CMRO2	16	MRI	14% FiO2
Smith et al.4	↑CMRO2	26	MRI	Stay at high altitude (3800 m)
Ainslie et al.6	−CMRO2	10	Doppler ultrasound; blood sampling.	90%–70% SaO2
	−CMRglu
	−CMRlac

⁻: denotes no change; ↑: denotes an increase.