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. 2016 Jun 13;6:27690. doi: 10.1038/srep27690

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Itraconazole was progressively titrated against 2 μM CYP51 (A) and 2 μM CYP5218 (B) with the difference spectra determined after each addition of triazole. Itraconazole saturation curves (C) were constructed from the type II absorbance difference spectra for CYP51 (filled circles) and CYP5218 (hollow circles). The data were fitted using a rearrangement of the Morrison equation⁴⁷. Each experiment was performed in triplicate although only one replicate is shown.