Table 1. Effects of in vivo PCB126 intranasal exposure (10 μg/Kg) on biochemical parameters and markers of renal and hepatic function.
Biochemical parameter concentration | Vehicle | PCB126 10 μg/kg |
---|---|---|
Glycaemia mg/dL | 94.60 ± 3.23 | 87.14 ± 3.21 |
Triglycerides mg/dL | 46.33 ± 2.14 | 106.2 ± 8.43*** |
Cholesterol mg/dL | 69.60 ± 1.94 | 88.27 ± 1.62*** |
High density lipoprotein (HDL) mg/dL | 61.22 ± 1.99 | 69.33 ± 4.618 |
Very low density lipoprotein (VLDL) mg/dL | 11.00 ± 1.18 | 21.23 ± 1.69*** |
Gamma-glutamyl transpeptidase (GTT) U/L | 5.67 ± 2.14 | 17.13 ± 1.84** |
Aspartate aminotransferase (AST) U/L | 86.67 ± 6.75 | 96.28 ± 11.26 |
Alanine aminotransferase (ALT) U/L | 43.30 ± 2.34 | 39.91 ± 6.32 |
Urea mg/dL | 42.64 ± 2.26 | 49.35 ± 3.17 |
Creatinine mg/dL | 0.6 ± 0.06 | 1.3 ± 0.08*** |
Total protein (urine) g/dL | 5.75 ± 0.11 | 6.12 ± 0.12* |
*P < 0.05,
**P < 0.01,
***P < 0.001 vs vehicle group. Data represents Mean ± SE, n = 5–6.