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Drosophila melanogaster (fruit fly) eye model exhibits neurodegeneration due to accumulation of amyloid-beta 42 (Aβ42) plaques.
Accumulation of Aβ42 plaques in (A) healthy neuron triggers (B) death of a meuron. (C, D) Misexpression of human Aβ42 in healthy photoreceptor neurons of Drosophila eye using transgenic approach causes a (C) wild-type adult compound eye to change into a (D) highly reduced adult eye due to induction of neuronal cell death (Tare et al., 2011).
