Table 3.

Change in SF-36 domains at 12 mo with home ventilation compared to baseline across studies and disease states.

Disease state	Study	n	Physical capacity					Mental capacity
			PF	RP	BP	GH	PCS	Vi	SF	RE	MH	MCS
RTD	Windisch et al. [7]	29	NC	NC	NC	NC	NC	+	+	+	+	NC
	Hein et al. [13]	8	NC	NC	NC	NC	NR	+	NC	NC	+	NR
	Nauffal et al. [12]	35	NC	+	NC	NC	NR	NC	+	+	NC	NR
	Tsolaki et al. [6]	17	NR	NR	NR	NR	+	NR	NR	NR	NR	+
NMD	Windisch et al. [7]	17	NC	NC	NC	NC	NC	NC	+	NC	NC	NC
	Hein et al. [13]	8	NC	NC	NC	NC	NR	NC	NC	NC	+	NR
	Nauffal et al. [12]	27	—	NC	NC	NC	NR	NC	NC	NC	NC	NR
	Bourke et al. [3]∗	41	NC	NC	NC	+	NC	+	NC	NC	+	+
	Bourke et al. [3]†	20	NC	NC	NC	+	NC	+	+	+	+	+
	Tsolaki et al. [6]	11	NR	NR	NR	NR	NC	NR	NR	NR	NR	NC
OHS	Windisch et al. [7]	9	+	+	NC	+	+	+	NC	+	+	+
	Tsolaki et al. [6]	28	NR	NR	NR	NR	+	NR	NR	NR	NR	+

BP, bodily pain; GH, general health; MH, mental health; NC, no change; NMD, neuromuscular disorders; NR, not reported; OHS, obesity hypoventilation syndrome; PF, physical function; RE, role emotional; RP, role physical; RTD, restrictive thoracic diseases; SF, social functioning; Vi, vitality; +, statistically significant improvement; —, statistically significant deterioration.

^∗Amyotrophic lateral sclerosis (ALS) only; ^†ALS with preserved bulbar function. There were no improvements within any of the domains in the poor bulbar function subgroup.