Table 1.
OPAT patient characteristics and outcomes.
| Variables | Total (n = 104) |
Return to ED or readmission (n = 48) |
No return to ED or readmission (n = 56) |
p value |
|---|---|---|---|---|
| Age, years [median (IQR)] | 63 (43–74) | 64 (43–74) | 61 (45–75) | 0.95 |
| Male | 65 (63%) | 28 (58%) | 37 (66%) | 0.42 |
| Length of stay, days [median (IQR)] | 7 (6–10) | 7 (6–10) | 7 (6–10) | 0.28 |
| Admitting service | ||||
| Medical | 47 (45%) | 23 (48%) | 24 (43%) | 0.61 |
| Surgical | 57 (55%) | 25 (52%) | 32 (57%) | 0.61 |
| Prior admission within past 12 months | 59 (57%) | 31 (65%) | 28 (50%) | 0.13 |
| History of antibiotic-resistant organisms | 24 (23%) | 13 (27%) | 11 (20%) | 0.37 |
| Comorbidities | ||||
| Hypertension | 46 (44%) | 24 (50%) | 22 (39%) | 0.27 |
| Diabetes | 29 (28%) | 18 (38%) | 11 (20%) | 0.04 |
| Gastrointestinal disease | 29 (28%) | 16 (33%) | 13 (23%) | 0.25 |
| Cancer | 27 (26%) | 17 (35%) | 10 (18%) | 0.04 |
| Coronary artery disease | 23 (22%) | 7 (15%) | 16 (29%) | 0.09 |
| Peripheral vascular disease | 13 (13%) | 6 (13%) | 7 (13%) | 1.00 |
| Arrhythmia | 12 (12%) | 5 (10%) | 7 (13%) | 0.74 |
| Documented follow-up plan at discharge | ||||
| Admitting service | 71 (68%) | 32 (67%) | 39 (70%) | 0.75 |
| Infectious diseases | 58 (56%) | 27 (56%) | 31 (55%) | 0.93 |
| Family physician | 35 (34%) | 13 (27%) | 22 (39%) | 0.19 |
| Most common antimicrobials1 | ||||
| Ceftriaxone | 22 (21%) | 10 (21%) | 12 (21%) | 0.94 |
| Cefazolin | 21 (20%) | 8 (17%) | 13 (23%) | 0.41 |
| Piperacillin-tazobactam | 15 (14%) | 4 (8%) | 11 (20%) | 0.10 |
| Cloxacillin | 15 (14%) | 10 (21%) | 5 (9%) | 0.08 |
| Vancomycin | 14 (13%) | 6 (13%) | 8 (14%) | 0.79 |
| Ertapenem | 13 (13%) | 8 (17%) | 5 (9%) | 0.23 |
| Syndrome | ||||
| Surgical site infection | 34 (33%) | 14 (29%) | 20 (36%) | 0.48 |
| Osteoarticular infection2 | 29 (28%) | 13 (27%) | 16 (29%) | 0.87 |
| Bacteremia | 22 (21%) | 14 (29%) | 8 (11%) | 0.06 |
| Cellulitis | 18 (17%) | 9 (19%) | 9 (16%) | 0.72 |
| Urinary tract infection | 16 (15%) | 12 (25%) | 4 (7%) | 0.01 |
| Endocarditis | 7 (7%) | 4 (8%) | 3 (5%) | 0.70 |
| Patient outcomes3 | ||||
| No events | 56 (54%) | — | 56 (100%) | — |
| Events due to infection relapse | 17 (16%) | 17 (35%) | — | — |
| Events due to treatment failure | 6 (6%) | 6 (13%) | — | — |
| Events due to OPAT-related complications | 11 (11%) | 11 (23%) | — | — |
| Events due to unrelated causes | 14 (13%) | 14 (29%) | — | — |
Values are expressed as number (%) unless otherwise stated.
1Less commonly used antimicrobials included ciprofloxacin, metronidazole, meropenem, clindamycin, fluconazole, cephalexin, rifampin, ceftazidime, ampicillin, penicillin G, nitrofurantoin, doxycycline, and voriconazole.
2Including 4 cases of diabetic foot infections and 1 case of prosthetic joint infection.
3Event defined as readmission or emergency department (ED) visit within 60 days of discharge.
IQR: interquartile range.