Table 1.
Description of model parameters and their values.
| Parameter | Description | Value | References |
|---|---|---|---|
| γ n | Stimulation rate of naïve B cells | 0.5 (antigen) −1 h−1 | [24] |
| μ n | Activation rate of B cells | 5.88 × 10−2 (MHC II)−1 h−1 | [25] |
| γ m | Stimulation rate of memory B cells | 1 (antigen) −1 h−1 | Estimated |
| μ m | Activation rate of memory B cells | 1 (MHC II)−1 h−1 | Estimated |
| α | Rate of MHC II antigen presentation | 6 h−1 | [23] |
| β | Binding rate of antibody with antigen | 60 (antigen molecule) −1 h−1 | [28] |
| δ n | Death rate of naïve B cells | 4.16 × 10−3 h−1 | [31] |
| δ m | Death rate of memory B cells | 2.1 × 10−4 h−1 | Estimated |
| δ a | Activation-induced cell death rate in the absence of antigen | 6.67 × 10−2 h−1 | [31] |
| δp | Death rate of plasma B cells | 8.33 × 10−3 h−1 | [29–31] |
| δ b | Antibody removal rate | 8.33 × 10−3 h−1 | [31] |
| d g | Antigen removal rate | 8.33 × 10−3 h−1 | Estimated |
| ρ | Production rate of naïve B cells from bone marrow | 10 day−1 | [41] |
| η | Rate of antibody production from plasma B cells | 7.2 × 106 (cell)−1 h−1 | [27] |