Table 2.
Effect of iron supplementation versus placebo on maternal outcomes.
| Outcome | Ironb | N | Placebo | N | Relative Risk (95% CI) | P Value |
|---|---|---|---|---|---|---|
| Placental malariaa | ||||||
| Microscopic – no. (%) | 11 (2) | 471 | 10 (2) | 487 | 1.14 (0.49, 2.65) | 0.77 |
| Submicroscopic – no. (%) | 26 (5) | 486 | 24 (5) | 501 | 1.12 (0.65, 1.92) | 0.69 |
| Any placental malaria – no. (%) | 33 (7) | 493 | 33 (6) | 510 | 1.03 (0.65, 1.65) | 0.89 |
| Placental weight (g) | 458 (140) | 443 | 456 (144) | 467 | 0.97 | |
| Maternal death – no. (%) | 2 (0) | 750 | 3 (0) | 750 | 0.67 (0.11, 3.98) | 1.00 |
| Maternal hospitalizations – no. (%) | 20 (0.4) | 4380 | 36 (0.8) | 4474 | 0.57 (0.32, 1.02) | 0.06 |
| Malaria – no. (%) | 2 (0) | 4380 | 7 (0.2) | 4474 | 0.29 (0.06, 1.40) | 0.12 |
| Other – no. (%) | 18 (0.4) | 4380 | 29 (0.1) | 4474 | 0.60 (0.33, 1.11) | 0.10 |
a
Microscopic infections were detected by placental histopathology. Submicroscopic infections were detected by qPCR on maternal placental tissue. Five participants (iron n=4, placebo n=1) had both microscopic and submicroscopic infections.
b
Means (SD) for continuous variables.