. Author manuscript; available in PMC: 2017 Jan 1.

Published in final edited form as: Cancer Control. 2016 Jan;23(1):12–20. doi: 10.1177/107327481602300104

Table 2.

Select Treatment-Related Adverse Events of Intralesional Therapy

Type of Therapy	Adverse Events
Bacille-Calmette-Guerin^21,28–30	Angioedema in the setting of positive tuberculin test Arthralgia Bacille-Calmette-Guerin granulomas Chills Diaphoresis Disseminated intravascular coagulation Granulomatous hepatitis Lymphadenopathy Malaise Pneumonitis
Electrochemotherapy + bleomycin/cisplatin^22,35	Pain at injection site, ulcerations
Granulocyte macrophage colony-stimulating factor³⁴	Flulike symptoms
Interleukin 2^18,36	Flulike symptoms Injection site pain/erythema
Rose bengal 10%^12,13,23,37	Blistering Edema Headache Local pain Inflammation Pruritus Skin discoloration Vesicles
Talimogene laherparepvec^9,39,40	Cellulitis Chills/rigors Fatigue Pyrexia
Velimogene aliplasmid^{16,19,24–27}	Asthenia Fatigue Flulike symptoms Injection-site pain Myalgia Paresthesia Rigor