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. Author manuscript; available in PMC: 2016 Jun 13.
Published in final edited form as: Mol Cell. 2015 Feb 26;57(6):1011–1021. doi: 10.1016/j.molcel.2015.01.026

Figure 5. Extracellular MBP-1 Amyloid Deposits in Eosinophilic Tissue.

Figure 5

(A) Skin biopsy from a Wells’ syndrome patient. Histology shows typical collagen bundles; i.e., flame figures (red box). Scale bar, 100 μm.

(B) The area contains amyloids stained by Congo red that appear pale red in bright-field mode. When visualized between crossed polarizer and analyzer, yellow-green birefringence was present.

(C) Immunofluorescence analysis showed large extracellular MBP-1 deposition that partly overlapped with the CR fluorescence.

(D) In contrast, no EPO protein was detected.