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. Author manuscript; available in PMC: 2016 Jun 13.
Published in final edited form as: Mol Cell. 2015 Feb 26;57(6):1011–1021. doi: 10.1016/j.molcel.2015.01.026

Figure 6. A Model For the MBP-1 Self-Association Cycle.

Figure 6

(A) MBP-1 condensation begins before/at the same time of pro-protein processing in granules. The process is followed by compaction of the cores. Granule biogenesis occurs during eosinophil differentiation.

(B) A number of mature specific granules with a crystalline interior are dispersed in the cytosol.

(C) Following eosinophil activation, the granule pH drops, and the content is mobilized, unpacked, and released through secretory vesicles.

(D) MBP-1 exerts its antibacterial effect through aggregation.

(E) MBP-1 toxicity toward host cells is also mediated by aggregation.

(F) Under conditions of sustained activation and massive secretion of MBP-1, extracellular deposition of MBP-1 can take place. Parallel arrows indicate amyloid aggregates, scissors represent the unknown protease processing pro-MBP-1, and active and toxic MBP-1 are shown as gray ellipses.