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. Author manuscript; available in PMC: 2016 Jun 13.
Published in final edited form as: Cell Host Microbe. 2016 May 11;19(5):686–695. doi: 10.1016/j.chom.2016.04.005

Figure 4. Vpu Downregulates HLA-C Specifically and Not HLA-B or HLA-A.

Figure 4

Primary CD4+ cells were infected in vitro with the HIV molecular clone WITO (top) or a mutant of WITO that does not express Nef (bottom). Cytometry staining of HLA-A, HLA-B, or HLA-C is shown for infected (red) and uninfected cells (black) and for an isotype control (gray). Infected cells within cultures were discriminated by co-staining for the viral protein Gag. CD4 cells were derived from donors homozygous for the A*02:01, B*44:02, C*0501 haplotype. See also Figure S5.