Table 2.

Univariate and multivariate analyses of survival for pN2 NSCLC

	Variable	Overall survival				Cancer specific survival				Recurrence-free survival
		Uni	Multivariate			Uni	Multivariate			Uni	Multivariate
		p	HR	95% CI	p	p	HR	95% CI	p	p	HR	95% CI	p
Age
	<65/≥65	0.051				0.496				0.097
Sex
	male/female	0.775				0.971				0.414
Clinical T factor
	T3-4/T1-2	0.022	1.002	0.983–1.021	0.823	0.033	1.004	0.982–1.027	0.696	0.107
Clinical N factor
	cN1-2/cN0	0.001	1.051	1.005–1.099	0.030	0.021	1.292	0.893–1.870	0.174	0.017	1.035	0.996–1.076	0.078
pm factor
	pm1-2/pm0	0.003	1.042	1.015–1.070	0.002	0.000	2.071	1.439–2.982	0.000	0.001	1.040	1.014–1.065	0.002
Operation
	lob/pn	0.194				0.882				0.271
Number of zones
	multiple/single	0.002	1.616	1.175–2.221	0.003	0.018	1.537	1.051–2.248	0.027	0.007	1.457	1.089–1.950	0.011
Tumor size
	>31 mm/≤30 mm	0.000	1.013	1.005–1.021	0.002	0.001	1.740	1.192–2.538	0.004	0.004	1.008	1.001–1.014	0.032
Skip
	Skip/nonskip	0.341				0.862				0.719
Adjuvant therapy
	yes/no	0.076				0.052				0.194
Pathology
	AD/non AD	0.496				0.772				0.276

pN2: pathologic N2; NSCLC: non-small cell lung cancer; Uni: Univariate; HR: hazard ratio; CI: confidence interval; pm: pulmonary metastatis; AD: adenocarcinoma; lob: lobectomy; pn: pneumonectomy