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. 2015 Jan 7;2(2):e982378. doi: 10.4161/23723556.2014.982378

Figure 1.

Figure 1.

Regulation of mitochondrial ATP production by OPA1. Members of the SLC25A family of mitochondrial inner membrane transporters sense the levels of mitochondrial metabolites. Starvation leads to a decrease in metabolites, promoting interaction between the transporters and OPA1. This leads to OPA1 oligomerization, reduced cristae width, increased assembly of the ATP synthase, and formation of respiratory supercomplexes, all of which improve mitochondrial efficiency. Conversely, when nutrient levels are high, less OPA1 oligomerizes and mitochondrial ATP production is less efficient. Importantly, these changes occur in a fusion-independent fashion. α-KG, α-ketoglutarate; AGC, aspartate/glutamate carrier; DIC, dicarboxylate carrier; Glu, glutamate; IM, inner membrane; IMS, intermembrane space; Mal, malate; OGC, oxoglutarate carrier; OM, mitochondrial outer membrane; Pi, phosphate; Succ, succinate.