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Gain-of-function mutant p53 inhibits adenosine monophosphate-activated protein kinase (AMPK) activation in head and neck squamous cell carcinoma. The wild-type p53 protein functions indirectly both upstream and downstream of AMPK. The gain-of-function mutant p53 functions directly upstream of AMPK and inhibits its activation, impairing the metabolic checkpoint and increasing anabolic tumor growth and progression.
