Table 2.

Correlations between regulators of apoptosis execution and clinicopathologic or outcome data

	Correlation analyses					Materials
Reference	Phenotype of interest	Tested for correlation with	Corr.	p value	Test	Analyzed	Tissue/Serum	Sample size
Apaf-1
Fujimoto et al.34	APAF-1 LOH	Overall survival	no	0.43	Log-rank test	gDNA	tissue	52 PMs
	APAF-1 LOH	Overall survival	yes	0.049	Log-rank test	gDNA	tissue	97 MMs
Fujimoto et al.35	APAF-1 LOH	Overall survival	yes	0.046	Log-rank test	gDNA	serum	44 MMs
Niedlojadlo et al.36	Apaf-1 mRNA expression	Clark level	yes	0.03	Pearson's corr coeff	mRNA	tissue	53 PMs
	Apaf-1 mRNA expression	Breslow thickness	no	0.38	Pearson's corr coeff	mRNA	tissue	53 PMs
	Apaf-1 protein expression	Clark level	yes	0.037	Pearson's corr coeff	protein	tissue	53 PMs
	Apaf-1 protein expression	Breslow thickness	no	0.23	Pearson's corr coeff	protein	tissue	53 PMs
Dai et al.39	Apaf-1 protein expression	Breslow thickness	no	> 0.05	Chi-square	protein	tissue	70 PMs
	Apaf-1 protein expression	Tumor ulceration	no	> 0.05	Chi-square	protein	tissue	70 PMs
	Apaf-1 protein expression	5-year survival	no	> 0.05	Log-rank test	protein	tissue	70 PMs
Zanon et al.40	Apaf-1 protein expression	Patient survival	no	Unknown	Unknown	protein	tissue	16 PMs + 66 MMs
Bachmann et al.41	Apaf-1 protein expression	Tumor thickness	yes	0.05	Unknown	protein	tissue	153 mixed samples
	Apaf-1 protein expression	Overall survival	no	0.095	Log-rank test	protein	tissue	153 mixed samples
Caspases
Woenckhaus et al.49	Active caspase-3 expression	Survival time	no	> 0.5	Cox regression	protein	tissue	66 mixed samples
	Active caspase-6 expression	Survival time	no	> 0.5	Cox regression	protein	tissue	66 mixed samples
XIAP
Hiscutt et al.55	XIAP protein expression	Stage	yes	< 0.001	Wald chi-square	protein	tissue	55 mixed samples
ML-IAP
Gong et al.57	ML-IAP protein expression	Patient age	yes	0.0056	Spearman rank corr	not specified	tissue	48 mixed samples
Takeuchi et al.58	ML-IAP mRNA expression	Overall survival	no	> 0.05	Unknown	mRNA	tissue	63 MMs
Nachmias et al.59	ML-IAP protein expression	Response to treatment	yes	0.02	Fisher's exact test	protein	tissue	27 PMs
XAF1
Ng et al.65	XAF1 protein expression	Tumor thickness	no	0.119	Chi-square	protein	tissue	70 PMs
	XAF1 protein expression	5-year survival	no	0.889	Log-rank test	protein	tissue	69 PMs
	XAF1 nuclear positivity	5-year survival	no	0.896	Log-rank test	protein	tissue	69 PMs

Abbreviations used: Coeff, coefficient; Corr, correlation.