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Senescence-associated cytokines establish an inflammatory microenvironment and promote cancer progression. Upon oncogene activation cells become senescent. The senescent cells produce and secrete the senescence-associated secretory phenotype (SASP), which reinforces senescence within the lesion and recruits immune cells to the surrounding tissue. The immune cells, along with the SASP, generate an inflammatory microenvironment, which in certain contexts fuels cancer progression.
