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. 2015 Sep 23;6(4):202–211. doi: 10.1080/21541248.2015.1085485

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© 2015 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 4. — ZOL treatment inhibits Rab prenylation in vivo in mouse peritoneal macrophages. Mice (3 per group) were administered either (A) a single i.p., s.c. or i.v. injection of 100 μg/kg ZOL or left untreated (cntrl), or (B) administered s.c. ZOL (n = 2 mice) or saline control (2 mice per group) once-weekly for 8 weeks. 24 hours after the final injection, cell lysates were prepared from CD11b⁺ macrophages isolated from peritoneal lavage fluid. After in vitro prenylation with Rab GGTase, samples were transferred onto blots and analyzed for the presence of biotinylated Rab proteins. The 75 kD band of endogenous biotinylated protein was used as a loading control.