Figure 2.

Scheme of the biochemical reactions described by the mathematical model of excitable Rho dynamics (adapted from Ref. 21). Inactive Rho (green rectangles) shuttles between the membrane and the cytoplasm and becomes converted into the active form (red rectangle) by Ect2. Active Rho promotes actin polymerization that, in turn, facilitates Rho inactivation, possibly, by recruiting a Rho GAP. In the absence of Rho activity, F-actin depolymerizes and recycles back into the cytoplasm.