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Contrasting roles of the P2X7 receptor (P2RX7) in the host–tumor interaction. Whether tumor (red) or host (green) P2RX7-dependent actions prevail will dictate whether a tumor will progress and metastasize or be successfully restrained by the host immune response. VEGF, vascular endothelial growth factor; DC, dendritic cell; IL-1β, interleukin-1β; ROS, reactive oxygen species.
