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. 2015 May 26;2(4):e1054549. doi: 10.1080/23723556.2015.1054549

Figure 4.

Figure 4.

Inhibition of JNK and p38 activation induces resistance to erastin in HL-60 cells. (A) HL-60 cells were treated with erastin (5 μM) for 24 h and subjected to western blot analysis of the indicated proteins in whole cell extracts. (B, C) HL-60 cells were treated with erastin (5 μM) with or without the indicated inhibitors for 24 h and cell viability was assayed (n=3, *P < 0.05 versus erastin treatment group) (B). In parallel, HMGB1 in the supernatant was analyzed using western blotting (C). (D) The indicated p38α knockdown HL-60 cells were treated with erastin (5 μM) for 24 h and cell viability was assayed (n=3, *P < 0.05).