Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Tight control of YAP half-life. Mechanotransduction through Rho proteins and the actin cytoskeleton regulates the phosphorylation of YAP by the upstream kinases Lats1/2 and its degradation by proteasomes. Nutritional cues and TSC mutations leading to mTOR activation regulate degradation of YAP by lysosomes through the autophagy pathway.
