Skip to main content
. 2015 Dec 10;3(2):e1074336. doi: 10.1080/23723556.2015.1074336

Figure 1.

Figure 1.

Novel network implicating microRNAs (miRs) in epithelial-mesenchymal transition (EMT) and metastasis. This schematic summary shows the major players leading to the development of colorectal cancer metastasis as described in our network and incorporating other key molecules published by other groups. The details of these interactions are described in part in this manuscript and completely in the original publications.1,3 APC, adenomatous polyposis coli; CASR, calcium-sensing receptor (also known as FIH); CXCL8, chemokine (C-X-C motif) ligand 8 (commonly known as IL 8); DAPK1, death associated protein kinase 1; E-cadherin, epithelial cadherin, also known as CDH1); FOXN, forkhead box N3; HIF1A, hypoxia inducible factor 1, α subunit; N-cadherin, neuronal cadherin (also known as CDH2); PI3K, phosphatidylinositol-4,5-bisphosphate 3-kinase; SETD2, SET domain containing 2; (SIAH1) siah E3 ubiquitin protein ligase 1; TGFBR2, transforming growth factor, β receptor II; TP53, tumor protein p53 (best known as p53); SRC, SRC proto-oncogene, non-receptor tyrosine kinase; VEGF, vascular endothelial growth factor; ZEB, zinc finger E-box binding homeobox.