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. 2016 Feb 18;3(2):e1106635. doi: 10.1080/23723556.2015.1106635

Figure 1.

Figure 1.

MDM2/MDMX gene amplification in RB wild-type (WT) or RB-deficient cancers with wild-type tumor protein p53. (A) Overexpression of MDM2/MDMX in cancers with WT p53 and RB leads to inactivation of both p53 and RB pathways, resulting in cell proliferation and cancer development. (B) Overexpression of MDM2/MDMX in cancers with WT p53 but RB deficiency inhibits E2F/p53-mediated apoptosis. E2F, E2F family of DNA binding transcription factors; MDM2, mouse double minute 2 homolog; MDMX, double minute X human homolog, also known as MDM4; RB, retinoblastoma protein.