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Genome-wide screen for modulators of rapamycin-induced mitophagy by synthetic array technology (SQA). Principle of SQA technology (top, left) and results of the quantitative genome-wide screen are shown (top, right). The Ubp3-Bre5 deubiquitination complex was identified as a negative modulator of mitophagy but a positive modulator of ribophagy, the cytoplasm-to-vacuole targeting (Cvt) pathway, and non-selective bulk autophagy (bottom).
