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. 2015 Dec 22;3(2):e1120845. doi: 10.1080/23723556.2015.1120845

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© 2016 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 1. — EglN2 forms an activator complex with PGC1a and NRF1 on chromatin and regulates mitochondrial function. EglN2 interacts with PGC1a and NRF1 on chromatin to positively regulate mitochondrial related genes and mitochondrial function in tumor. This trimeric complex interaction becomes much stronger under hypoxia in order to sustain mitochondrial function for maintenance of tumor growth. FDXR is one of their downstream target genes that mediates this regulation.