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. 2016 Feb 10;7(10):10827–10840. doi: 10.18632/oncotarget.7312

Figure 1. An integrative pipeline for the construction of global triple network and CHLMN.

Figure 1

Interactions between lncRNAs and miRNAs were provided from starbase database and miRanda prediction tools. The interactions between miRNAs and mRNAs were provided from starbase. The global triple network was constructed by merging all the interactions of lncRNA-miRNA, miRNA-mRNA. Mapping the CH related differential expressed lncRNAs and mRNAs (computed from gene expression profile) into the global triple network. If differential expressed lncRNAs and mRNAs shared the same miRNAs could add an edge between them, using hypergeometric test, then the CHLMN was constructed.