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. 2016 Feb 19;7(10):10857–10869. doi: 10.18632/oncotarget.7516

Figure 6. Gene expression of steroid receptors in the baboon endometrium treated with progesterone and antiprogestin (EC304).

Figure 6

A. mRNA expression of estrogen receptors (ER and PR) was elevated in the endometrium of baboons treated with P+EC304 when compared to progesterone alone treated group. The increased expression of ER induced proliferation is further evidenced by increased expression of cyclin D1. B. Gradual progression of endometriotic lesion was analyzed by histology and immunohistochemistry. Levels of PR remained unchanged, however the proliferation marker such as Ki67 showed unopposed estrogenicity induced by antiprogestin treatment.