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In tumor cells with a high ratio of MIG6/ERBB receptors, MIG6 inhibits the receptor kinase activity and promotes their internalization for lysosomal degradation, resulting in a dramatic reduction of ERBB oncogenic signaling. In tumor cells with a low MIG6/ERBB ratio, MIG6 activity is reduced and ERBB oncogenic signaling is restored. Consequently, tumor cells may be more sensitive to ERBB-like inhibitors.
