Skip to main content
. 2016 Jan 31;7(10):11056–11066. doi: 10.18632/oncotarget.7090

Figure 2. The miRNA signature of mutp53 associated with disease-free survival of gastric cancer patients.

Figure 2

Comparison of survival in all panels were performed using Kaplan-Meier test. (A) The schematic diagram showing the analysis flow. A partial mutp53 signature was derived by overlapping mutp53-regulated miRNAs and abundantly expressed miRNAs in gastric cancer. a non-negative matrix factorization (NMF) model was used to classify the cancer patients based on the miRNA signature, followed by DFS comparison between different groups. (B) The survival of gastric cancer patients with different AJCC stages were compared using Kaplan-Meier survival test (P-value indicated). (C–D) DFS of patients in 3 subgroups determined by NMF clustering based on either the miRNA signature (C) or all miRNAs (D). (E–F) Comparison of patient DFS in 4 subgroups as determined based on miRNA signature (E) or all miRNAs (F).