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. 2016 Jan 25;7(10):11263–11270. doi: 10.18632/oncotarget.7019

Figure 4. Effect of the compound SRI-20039 on Wnt/β-catenin signaling in colorectal cancer cells and cancer cell viability.

Figure 4

A. The structure of SRI-20039. B. HCT116 cells in 24-well plates were transiently transfected with Super8XTOPFlash construct and β-galactosidase-expressing vector in each well. After being incubated for 24 h, cells were treated with SRI-20039 at the indicated concentrations for 24 h. The luciferase activity was then measured 24 h later with normalization to the activity of the β-galactosidase. Values are averages of three determinations with the SD indicated by error bars. C. HCT116 cells in 96-well plates were treated with SRI-20039 for 72 h. Cell viability was measured by the Cell TiterGlo assay. All the values are the average of triplicate determinations with the SD indicated by error bars.