Table 1. Activity data on the lead compounds.
| ID | MWT | CLogPa | PSAa | Wnt reporter activity in HCT116 cells, IC50 (μM) | Cell viability, IC50 (μM) | ||
|---|---|---|---|---|---|---|---|
| HCT116 | SW480 | SW620 | |||||
| SRI-28875 | 395 | 6.2 | 39.9 | 14.7 | 11.9 | 17.4 | 13.6 |
| SRI-28876 | 409 | 6.9 | 39.9 | 6.6 | 7.9 | 13.5 | 10.2 |
| SRI-28998 | 423 | 7.3 | 39.9 | 6.0 | 5.2 | 7.0 | 8.2 |
| SRI-29072 | 427 | 6.7 | 48.7 | 22.3 | 8.8 | 12.3 | 6.0 |
| SRI-29155 | 441 | 7.5 | 48.7 | 9.7 | 8.5 | 8.9 | 9.2 |
| SRI-29213 | 455 | 7.8 | 48.7 | 8.9 | 4.9 | 5.8 | 7.1 |
| SRI-31230 | 332 | 5.5 | 39.9 | 12.7 | 6.2 | 5.9 | 6.7 |
a
CLogP and Polar Surface Area (PSA) were calculated using ChemBioDraw Ultra 2010.