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. 2015 Dec 11;7(10):11364–11379. doi: 10.18632/oncotarget.6575

Figure 7. hTERT, c-Myc and Hpa expression levels are positively related and associated with a poor prognosis in gastric cancer.

Figure 7

A. The expression level of c-Myc was semi-quantitatively analyzed using immunochemistry. The relative expression level of c-Myc was determined in gastric cancer and corresponding adjacent normal tissues (P < 0.0001). B. and C. Correlation of the protein expression levels of hTERT, c-Myc and heparanase were analyzed using Pearson's correlation analysis. D. Kaplan-Meier analysis of overall survival in GC patients with different hTERT, c-Myc and heparanase expression. E. Model for the transcriptional regulation of heparanase by hTERT in GC cells. hTERT translocates to the nucleus and binds to c-Myc to form a transcriptional complex, which then binds to heparanase promoter to promote its expression. hTERT upregulates c-Myc expression by activating Wnt/β-catenin signaling. In turn, c-Myc binds directly to hTERT promoter to transactivate hTERT, which forms a positive feedback loop to sustain high levels of hTERT as well as c-Myc.