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. 2015 Dec 22;7(10):11424–11433. doi: 10.18632/oncotarget.6717

Figure 5. Histone modifications on the Bmi1 promoter were changed in the in vitro sequence of pancreatic carcinogenesis.

Figure 5

(A) Epigenetic signature of three Bmi1 promoter regions (P1 to P3 in the direction from 5′ to 3′) analyzed with ChIP-RT-PCR using H3K4me3 and H3K27me3 antibody represented in three panels for acini, 3D-ADM and tumor cells. (B) Direct comparison of the H2AK119ub loss on the Bmi1 promoter regions in the in vitro sequence of acini, 3D-ADM and tumor cells. All ChIP-RT-PCR data are calculated as fold enrichment over IgG control and are represented as mean ± SEM (n = 3–5).