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. 2016 Feb 12;7(10):11708–11723. doi: 10.18632/oncotarget.7336

Figure 7. Proposed working model.

Figure 7

(A) Schematic representation of PEGylated liposomes encapsulating FLLL32 as spherical vesicles. FLLL32 (silver balls) and cholesterol (green balls) are encapsulated inside of the lipid bilayer formed by EPC (blue hydrophilic heads and deep yellow hydrophobic tails) with PEG coating (cyan sticks). (B) Schematic representation of FLLL32 delivery, intracellular releasing and affecting processes. Upon release from liposome in the cytosol, FLLL32 binds to the SH2 domain of STAT3, which inhibits the phosphorylation, dimerization and nuclear transloacation of STAT3 and subsequently transcription of STAT3 target genes. (C) Working model of combination therapy. Radiotherapy only eliminates proliferating cancer cells, while combination treatment results in both killing of proliferating cancer cells and eradicating of CSCs by Lip-FLLL32.